The film, written by Jim Mickle and Nick Damici and directed by Jim Mickle ("Mulberry Street"), takes place following a global spread of vampirism. McGillis plays a nun who joins a small team of survivors (including Damici, Danielle Harris of "Halloween" and "Halloween 2" and Conor Paolo of "Gossip Girl") as they make a treacherous journey north to safety through the war-torn U.S. McGillis' character, "Sister," faces a crisis of faith during the vampire bloodshed, ultimately taking up arms to do battle with her newly formed family unit.